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Reliability, Responsibility and Rapidity

Founded in 2007, focus on the synthesis of small molecule compounds and the extraction of some natural compounds. We develop, produce and sell high-quality advanced intermediates and some APIs with competitive prices.
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Contact Info

  • Building 2, Handa Science and Technology Park
    No. 8 Pioneer Road
    High-tech Zone. Suzhou.
  • 86 512 6803 2792
    86 512 6803 2791
  • willdyhan@pudeepharm.com
    sales@pudeepharm.com

Product Details

Abemaciclib Intermediate 1

Abemaciclib Intermediate 1 | 1231930-42-9

Chemical Name: 6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole

CAS Number: 1231930-42-9
Formula: C15H13ClF2N4
Molecular weight: 322.74

Product Description

"

Abemaciclib is a drug for the treatment of advanced or metastatic breast cancers. It was developed by Eli Lilly. and it acts as a CDK inhibitor selective for CDK4 and CDK6.[1] It was designated as a breakthrough therapy by the U.S. Food and Drug Administration in October 2015.[2]In September 2017, it was approved for use in the United States by the Food and Drug Administration for "adult patients who have hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer that has progressed after taking therapy that alters a patient’s hormones"

One of intermediates of Abemaciclib, the appearance is light-yellow solid, the purity is not less than 98% by HPLC.

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